Research

The main scientific directions in the field of hematology are related to the problems of diagnosis and treatment of malignant lymphomas and leukemias. In this context, the criteria of diagnosis and differential diagnosis of the specified hematological malignancies have been elaborated. There are performed the clinical and morphologic studies (histological and cytological) of malignant lymphomas, which contribute to the improvement of treatment modalities. About 80-85 % of patients diagnosed in localized stages are cured. The maintenance treatment during the complete remission in patients with generalized stage non-Hodgkin lymphomas has been elaborated and introduced into practice. As a result, these patients have experienced the increase of 5-year relapse-free survival, considered oncologic recovery, from 20 to 53%.  The clinical and hematological features of these pathologies have been studied with respect to localization of the primary tumor focus (gastrointestinal tract lymphoma, splenic lymphoma, etc.). Due to the multilateral researches of clinical and morphological age-related features of Hodgkin and non-Hodgkin lymphomas an important data have been obtained and used in diagnostics and treatment in children and adults.

There are elaborated the criteria of individualization of treatment programs for patients with acute leukemia and chronic myeloid leukemia. Important successes are achieved in the treatment of acute promyelocytic leukemia, which has been considered before as one of the most unfavorable types of acute leukemias. The inclusion of all-transretinoic acid in treatment program of this leukemia contributed to the increase of the complete remission rate and 5-year relapse-free survival rate up to 75 %. It has been proved that tyrosine kinase inhibitors constitute the first-line therapeutic option in treatment of chronic myeloid leukemia in chronic and accelerated phases, being superior to conventional chemotherapy and α-interferon due to the possibility of complete cytogenetic response and increase of patients life quality and lifespan.

The main research directions in the field of oncology are:

  1. Updates in celioscopic diagnosis and minimally invasive surgery (laparoscopic splenectomy) in hematological pathologies.
  2. Prophylaxis and treatment of acute postoperative pancreatitis in patients with gastric cancer.
  3. Diagnostic aspects of gastric cancer of intestinal type.
  4. Early diagnosis of tumors.
  5. Complex and combined treatment of patients with tumors.
  6. Rehabilitation of oncologic patients from clinical group III.
  7. Palliative treatment of oncologic patients from clinical group IV.
  8. Management of oncology service.

Theses supported in the field of oncology:

  1. Tudor Rotaru „ Combined and complex treatment of relapses and metastases of ovarian cancer in the small pelvis”. 14.00.14- Oncology and Radiotherapy. Year -2010.
  2. Oxana Pihut „Clinical, diagnostic aspects of secondary malignant tumors with unknown primary focuses”. 14.00.14 – Oncology and Radiotherapy. Year – 2010.
  1. Andrei Ţîbîrnă “ Clinico-morphological, epidemiological and surgical features of adenoma and thyroid gland cancer”. 14.00.14 – Oncology and Radiotherapy. Year – 2010.
  2. Tcacenco Ecaterina „Management of early diagnosis of skin tumors within the frame of private medical centre”. 14.00.33- Social Medicine and Management. Year – 2012.
  3. Rotaru Ghenadie  „Medico-social and psychological aspects of judge’s morbidity in Moldova”. 14.00.33- Social Medicine and Management. Year- 2010.
  4. Eftodii Diana  „Epidemiological, clinical and morphological aspects of skin tumors of mesenchymal origin”. 14.00.14– Oncology and Radiotherapy. Year – 2013.
  5. Ţurcan Stela “Modern surgical treatment of malignant melanoma”. 14.00.14- Oncology and Radiotherapy.

Theses planned in the field of oncology:

  1. Butucel Dumitru “Clinico-diagnostic aspects of treatment of hypogastric region tumors”. 14.00.14– Oncology and Radiotherapy.
  2. Dascaliuc Ion “Modern techniques and technologies in treatment of  tumors of pelvic bones and superior 1/3 of femoral bone”.
  3. Ciuperca Victor “Clinical and prosthetic management of patients with tumors of the bones of the inferior member”. 14.00.14– Oncology and Radiotherapy.
  4. Olaru Andrei „Clinico-diagnostic aspects and treatment of pathological vertebrae fractures of neoplastic origin”. 14.00.14– Oncology and Radiotherapy.
  5. Duda Boris, 27.09.13. “Percutaneous ecoguided nephrostomy as a minimally invasive method of supravezical urine derivation in advanced tumors of the small pelvis”. 14.00.14– Oncology and Radiotherapy.
  6. Corobcean Nadejda “Prophylaxis and treatment of acute postoperative pancreatitis in patients with gastric cancer”. 14.00.14– Oncology and Radiotherapy.
  7. Odobescu Oxana “Clinico-morphologic and surgical treatment features in phyllodes tumors of mammary gland”. 14.00.14– Oncology and Radiotherapy.

Data about the activity of doctorate fellows

at the Department of Oncology, Hematology and radiotherapy

 

Nr. d/o

Scientific chief (name, surname)

Doctorate fellow (name, surname)

 

Form of studies (daily/ extramural)

Autochthonous/ foreign

Research topic                 

1.

Corcimaru Ion, university professor

Mocanu Irina

Extramural

Autochthonous

Hemostasis during the induction of remission in patients with non-Hodgkin lymphomas

2.

Ghidirim Nicolae, university professor

Odobescu Oxana

Extramural

Autochthonous

Clinico-morphologic and surgical treatment features in phyllodes tumors of mammary gland

3.

Mereuţă Ion, university professor

Guzun Irina

Extramural

Autochthonous

Medico-social aspects of ophthalmologic morbidity and of “dry eye syndrome” and it’s prophylaxis in rural conditions

4.

Mereuţă Ion, university professor

Munteanu Nadejda

Extramural

Autochthonous

Management of the correction treatment of ophthalmologic pathologies in rural conditions

5.

Robu Maria, associate professor

Buruiană Sanda

Extramural

Autochthonous

Indolent non-Hodgkin lymphomas  (clinical, hematological, morphologic, immunologic and immunohistochemical  studies)